Fig. 1

Genome-wide chromatin 3D structure dynamics in response to nitrogen deprivation in N. oceanica. A Genome-wide chromatin interaction under C0, N1 and N2 in N. oceanica. B, C Genome-wide difference chromatin interaction map. The 20-kb and 2-kb binned heatmap (subtractive matrix) were shown by depicting the Z-score difference between C0 and N1, C0 and N2, or N1 and N2 (see “Methods” for Z-score difference calculation). D Averaged scaling plot of interaction frequencies against increasing genomic distance in N. oceanica. The genomic bin size is 100 kb. E Circos plots of the chromatin 3D structure of N. oceanica genomes. Seven rings from the outside to inside show genomic positions, gene expression FPKM (fragments per kilobase per million mapped reads) value, PC1 signal of A compartment (red) and B compartment (blue), and TAD-separation score for C0, N1 and N2, respectively