Fig. 3
From: Emerging methylation-based approaches in microbiome engineering
Diversity of DNA methyltransferases in the human microbiome. This figure classifies DNA methyltransferases from various bacterial species within the human microbiome using data from the REBASE database. A phylogenetic tree, color-coded by phylum, displays 150 bacterial species and is based on their 16S rRNA gene sequences. A A heat map details the distribution of Type I, II, III, IV, and orphan restriction-modification (R-M) systems across these species, while an adjacent bar plot shows the number of DNA methyltransferases per species, with Treponema succinifaciens registering the highest at 27. Donut charts (B) depict the prevalence of methylation types—5mC, 6mA, and unknown—across all methyltransferases and C the distribution of known versus unknown motifs within all R-M systems. D A bar plot enumerates the proportions of specific known methylation motifs for all R-M systems identified, with motifs appearing only once grouped as “Others”