Products | Coculture systems | Carbon source, precursor/ mid-products | Production before optimization | Optimization method | Coculture production | Refs |
---|---|---|---|---|---|---|
Caffeic acid | S. cerevisiae–S. cerevisiae–S. cerevisiae | Carboxymethyl-cellulose/ glucose, p-Coumaric acid | 8.33 mg/L | Adjusting environmental parameters | 16.91 mg/L | [143] |
Lipopeptide | C. glutamicum–B. amyloliquefaciens–P. pastoris | Kitchen waste/ L-proline, amylase |  ~ 29.77 mg/L* | Dividing metabolic pathways | 74.13 mg/L | [147] |
H2 | Enterococcus–Enterococcus–Enterococcus | Wheat-straw xylan | — | Dividing metabolic pathways | 79.54 mL/g wheat-straw xylan | [148] |
Lipid | R. opacus–R. jostii–R. jostii | Lignin, glucose/ acetyl-CoA, β-ketoadipyl-CoA | — | Reducing competition between species members | 0.08 g/g cell dry weight | [149] |
Lipopeptides | B. amyloliquefaciens–C. glutamicum–C. glutamicum–P. pastoris | Kitchen waste, glucose/ proline, serline, amylase |  ~ 193.47 mg/L* | Dividing metabolic pathways and enhancing the transport of essential metabolites | 269.17 mg/L | [150] |
Butyl Butyrate | C. acetobutylicum–C. tyrobutyricum-E. coli–T. asperellum | Microcrystalline cellulose/ lipase, acetate, butyrate, butanol | 13.52 g/L with glucose | Dividing metabolic pathways | 2.94 g/L without glucose | [151] |
Butyric acid | T. reesei–L. pentosus–C. tyrobutyricum–L. brevis | Cellulose, xylose/ acetate, lactate, butyrate, O2 | 9.5 g/L | Membrane separation | 10.2 g/L | [103] |
Electricity | S. elongatus-E. coli–S. oneidensis–G. sulfurreducens | CO2/ sucrose, lactate, acetate |  ~ 0.6 W·m−2 | Dividing metabolic pathways and adjusting environmental parameters | 1.7 W·m−2 | [152] |
Iturin A | B. amyloliquefaciens–B. subtilis–B. subtilis | Food waste/ amylase, lipase, glucose, fatty acid chain | 7.66 mg/L | Dividing metabolic pathways | 8.12 mg/L | [153] |