Fig. 1

Reaction scheme of E. coli central metabolism, overflow metabolism, stationary phase acetate production and mevalonate production. AcCoA = acetyl-CoA, HMG-CoA = 3-hydroxy-3-methylglutaryl-CoA, MVA = mevalonate, AACT = acetoacetyl-CoA thiolase, HMGR = 3-hydroxy-3-methylglutarate reductase, HMGS = 3-hydroxy-3-methylglutarate synthase, Pta = phosphate acetyltransferase, AckA = acetate kinase, PoxB = pyruvate oxidase, TCA = tricarboxylic acid, PDH = pyruvate dehydrogenase complex