Fig. 5

Evaluation of the safety and in vivo efficacy of PS–Kiadin–HH. A Cytotoxicity of PS–Kiadin–HH (Biosynthesis) against RAW264.7 cells. B Survival rate of E. coli K88 infected mice after treatment with PBS, biosynthetic PS–Kiadin–HH and chemical synthesis of PS–Kiadin–HH, respectively. E. coli K88 was used to construct an intraperitoneal infection model, 16 mice in each group. C Bacterial loads in hearts, livers, spleens, and kidneys from infected mice on the second day of treatment, with 5 mice in each group