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Table 1 Proteins of the ilicicolin H BGC from T. reesei in comparison to the homologs in Neonectria sp. DH2 [13] and T. variabilis [12]

From: Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei

Protein designation

Enzyme

function

JGI protein ID in T. reesei QM6a/RutC30

Homolog in Neonectria sp. DH2 (% identity)

Homolog in T. variabilis HXQ-H-1 (% identity)

TriliA

PKS-NRPS

58285/128011

IliA (63%)

IccA (59.8%)

TriliB

Enoyl reductase

58289/74247

IliB (65.3%)

IccB (68.6%)

TriliC

Cytochrome P450

58953/33667

IliC (70.7%)

IccC (69.4%)

TriliD

Diels-Alderase

–/75073

IliD (55.6%)

IccD (51.8%)

TriliE

Epimerase

76204/96728

IliE (52%)

IccE (55.9%)

TriliR

Transcription factor

72993/74475

Pred. TF (48.5%)

n/a